The liver is responsible for the production of most clotting factors. Which of the following best describes the role of these clotting factors when a blood vessel is broken?

A) When a vessel ruptures, clotting factors become activated to permit the conversion of soluble fibrinogen to insoluble fibrin.
B) When a vessel ruptures, clotting factors are immediately released from the liver, find the site of injury and then bind to prevent further blood loss.
C) Platelets are made in the liver and store clotting factors. When a vessel ruptures, platelets release these clotting factors which stop blood loss.
D) When a vessel ruptures, clotting factors from the liver stimulate vascular spasms which decrease blood loss from the site of injury.

When a blood vessel suffers any type of aggression, the body begins a process of homeostasis that prevents heavy bleeding by forming an aggregate of activated platelets, red blood cells and fibrin called thrombi or clots. The clotting factors released by the liver are responsible to form the components of the clot. Over 30 proteins will go through activation and modification to form clots to prevent blood loss.