Why are Acetyl-CoA and succinyl-CoA, both high energy thioesters, chemical energies put to different uses?
The energy released by hydrolysis of acetyl-CoA is needed for the condensation reaction that links acetyl moiety to oxaloacetate, yielding citrate. The energy released by hydrolysis of succinyl-CoA drives the phosphorylation of GDP, yielding GTP
Some reactions of the citric acid cycle are endergonic. Explain how the overall cycle is exergonic.
The sum of the energies of the individual reactions is -44.3kJ for each mole of acetyl-CoA that enters the cycle
Which enzymes of the citric acid cycle are missing from the glyoxylate cycle?
isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, and succinyl-CoA synthetase
