The hypoxemia , hypercapnia and decreased serum pH is responsible for respiratory failure in case of pneumothorax.
The respiratory failure occur only when partial pressure of PO₂ is less than 50 mm Hg or hypoxemia. It can also be marked when PCO₂ is >50 mm Hg or hypercapnia condition and decreased serum pH below 7.3.
With each exhalation, more and more air becomes trapped in the pleural cavity, compromising the unaffected lung and ultimately leading to the failure of both lungs. This condition is known as pneumothorax.
Hence, respiratory failure occur due to decreased partial pressure of oxygen.
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