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When two or more groups occupy distinct spaces in the same city, county, or even state, segregation is said to take place. Social exclusion and geographic segregation are virtually invariably linked.

While migrants' decisions to settle close to networks of friends, relatives, and people of the same ethnicity can contribute to segregation , these migrants may be compelled to live in more impoverished areas due to a lack of employment opportunities and affordable housing. Schools, hotels, bars, hospitals, restrooms, parks, even phone booths, and separate sections in libraries, movie theaters, and people in restaurants—the latter of which frequently had separate ticket windows and counters—were among the facilities that were segregation . The law of purity of gametes is another name for the segregation rule. This law states that when gametes arise, a gene's two alleles split apart. Instead of blending, they segregation or divide into various gametes. As a result, every gamete is "pure" and has just one allele of each gene.

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