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They do this by diapedesis, a process in which the leukocyte travels ameboid-like via closely apposed endothelial boundaries (paracellular transmigration) and, in some circumstances, through the endothelial cell itself (transcellular migration).
Neutrophils are generally present in the bloodstream, but they move quickly to infection sites in tissue. The trans-endothelial migration (TEM) of neutrophils can proceed either directly via individual endothelial cells (the transcellular pathway) or between them (the paracellular route)
Leukocytes move via gaps between blood vessel cells, and the process of attachment to transit through the blood vessel wall is referred to as diapedesis. Diapedesis is followed by a migration of leukocytes toward infection sites defined by a high concentration of inflammatory proteins.
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