Class IV and Class V mutations would be less likely to lead to Cystic Fibrosis (CF).
Class IV mutation or Conduction mutation involves reduced chloride conductance. It changes the shape of the protein channel so that chloride cannot move easily in and out of the cells. Less than 3% of people with cystic fibrosis in Europe have this type of mutation.
Class V or Insufficient Protein mutation is associated with reduced protein levels. It results in a reduction in the amount of CFTR protein produced by the cells. Less than 3% of people with cystic fibrosis in Europe have this type of mutation.
These two classes of mutations cause a milder reduction in CFTR function.
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