Hox genes, which are members of the homeotic transcription factor family, establish the segment identity of tissues within the embryo and are essential regulators of the body plan along the cranio-caudal axis (also known as the anterior-posterior axis). This means during embryogenesis, these genes expression follows a precise spatial and temporal colinearity pattern from the 3' to the 5' end of each cluster.
This indicates that Hox genes expressed anteriorly in the developing embryo are typically found at the 5′ end of the same genomic area, a phenomenon known as spatial colinearity. In comparison, those expressed posteriorly are typically found at the 3′ end of the Hox cluster.
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