Around 12 ATP equivalents are generated by the complete oxidation of one molecule of acetyl CoA.
Glycolysis begins when glucose enters, producing 2 pyruvate molecules. These pyruvates are subsequently transformed into two molecules of acetyl CoA. With each acetyl CoA that enters the citric acid cycle, three NADH (9 ATP), one FADH (2 ATP), and one GTP are produced (1 ATP). Each mole of acetyl-CoA will therefore yield 12 ATP molecules in total.
Electron transport from the citric acid cycle's energy precursors in step 3 causes oxidative phosphorylation, which phosphorylates ADP to produce ATP. In animals the majority of the energy required in biosynthesis, preserving appropriate ion balance, and mechanical work comes from oxidative phosphorylation.
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