Bowman's capsule collecting duct loop of Henle is the part of the nephron is responsible for the greatest possible increase in urine concentration.
Maximum concentration occurs at the bottom of the loop. The ascending limb of the nephron loop is impermeable to water, but Na + and Cl – are pumped out into the surrounding fluids by active transport.
The production of concentrated urine involves complex interactions among the medullary nephron segments [5;6] and vasculature. In outer medulla, the thick ascending limbs of the loops of Henle actively reabsorb NaCl.
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