Sperm release hyaluronidase to break down the bonds between adjacent follicle cells surrounding the oocyte.
- In mammalian fertilization, the sperm cell's acrosome releases hyaluronidase after reaching the oocyte, breaking down hyaluronan in the corona radiata to enable conception.
- Sperm hyaluronidase has been linked to sperm penetration of the cumulus oophorus' extracellular matrix and may be extremely important for gamete contact and mammalian reproduction.
- The hyaluronidase enzymes on the surface of the sperm help it break through this covering when a capacitated sperm reaches the ovum.
- When this happens, the sperm might connect to the zona pellucida. Hyaluronidase breaks the egg's vitelline membrane as part of its function.
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