N-Octanol and water are chosen because the connection between a substance's hydrophilicity and lipophilicity is measured by [tex]K_{OW}[/tex] (n-Octanol/Water partition coefficient). When a chemical is more dissolves in fat-like solvents like n-octanol, the value is more significant than one, when it's more dissolved in water, the value is lower.
What is the partition coefficient?
So, N-Octanol is chosen because it has a carbon/oxygen ratio that is comparable to that of lipids and because it shows both hydrophobic and hydrophilic properties. N-octanol, therefore, resembles the makeup and characteristics of cells and other living things.
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