A "faulty transcription factor" produced by a mutated p53 gene, prevents the transcription or translation of a polypeptide that prevents cell proliferation.
Tumor suppressor,p53 gene:
- The p53 gene, a tumor suppressor is frequently inactivated during the tumorigenic process. The p53 gene is often altered, producing a persistent mutated polypeptide whose development is thought to be a characteristic of cancer cells.
- In contrast to losing their tumor-suppressing properties, mutant p53 proteins frequently acquire new carcinogenic properties that provide cancer cells an edge in terms of both survival and proliferation.
- It is fascinating to note that p53 gene mutations have been linked to several stages of the multi-step malignant transformation process, each of which contributes differently to tumor start, amplification, competitiveness, and migration.
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