Answer:
I'm assuming your answer is:
Come on, Scott, unlock this door!
Explanation:
How often, should she take this medicine Doctor?
There should be a comma in front of Doctor, after medicine. The sentence should not have a comma after often and before should.
(How often should she take this medicine, Doctor?)
Alec where are, your soccer cleats?
The comma should be right after Alec's name, before the word where.
(Alec, where are your soccer cleats?)
Run Isaac, run!
I think that you need a comma after run, and before Isaac.
(Run, Isaac, run!)