Oxaloacetate is a key intermediate in the citric acid cycle, but it is also needed as a precursor for the synthesis of glucose during gluconeogenesis. Oxaloacetate is also fairly chemically unstable and undergoes spontaneous decarboxylation to pyruvate. Although oxaloacetate is not depleted by participation in the citric acid cycle, it can become depleted by other processes, necessitating its replenishment by various synthetic pathways. Use the Metabolic Map to identify enzymes that can replenish oxaloacetate or other citric acid cycle intermediates.

Replenishing oxaloacetate is done by carboxylating pyruvate into oxaloacetate through a process that is catalyzed by an enzyme called pyruvate carboxylase. This enzyme speed up the process and the replenishing of oxaloacetate occur quickly and the oxaloacetate is ready to function and participate in different chemical reactions.

Answer Link

mickymike92 mickymike92 · Answer 2 · 2022-03-15T12:40:36+01:00

Depleted oxaloacetate can be replenished by the carboxylation of pyruvate by the enzyme pyruvate carboxylase.

What is the citric acid cycle?

The citric acid cycle is a cycle which is important in aerobic respiration for the production of ATP.

One of the intermediates in the citric acid cycle is oxaloacetate.

Oxaloacetate combines with acetylcoA to form citric acid.

Depleted oxaloacetate can be replenished by the carboxylation of pyruvate by the enzyme pyruvate carboxylase.

Learn more about oxaloacetate at: https://brainly.com/question/8075492