A young child has recently been diagnosed with Pompe disease, which causes severe muscle weakness and muscle tone. The patient lacks the enzyme alpha-glucosidase (GAA). A lack of this enzyme leads to accumulation of the carbohydrate glycogen in muscle cells. Based on your knowledge of biological macromolecules, which argument best supports why this disease is occurring? Question 13 options: Glycogen is a protein and the enzyme, alpha-glucosidase, is not breaking it down into the lipid glucose. Glycogen is a protein and the enzyme, alpha-glucosidase, is not breaking it down into the nucleic acid glycerol . Glycogen is a polysaccharide and the enzyme, alpha-glucosidase, is not breaking it down into its monomer, fatty acids and glycerol. Glycogen is a polysaccharide and the enzyme, alpha-glucosidase, is not breaking it down into the monosaccharide glucose.

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lillygotcake123 lillygotcake123

01-09-2020
Biology

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A young child has recently been diagnosed with Pompe disease, which causes severe muscle weakness and muscle tone. The patient lacks the enzyme alpha-glucosidase (GAA). A lack of this enzyme leads to accumulation of the carbohydrate glycogen in muscle cells. Based on your knowledge of biological macromolecules, which argument best supports why this disease is occurring? Question 13 options: Glycogen is a protein and the enzyme, alpha-glucosidase, is not breaking it down into the lipid glucose. Glycogen is a protein and the enzyme, alpha-glucosidase, is not breaking it down into the nucleic acid glycerol . Glycogen is a polysaccharide and the enzyme, alpha-glucosidase, is not breaking it down into its monomer, fatty acids and glycerol. Glycogen is a polysaccharide and the enzyme, alpha-glucosidase, is not breaking it down into the monosaccharide glucose.

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marianaegarciaperedo marianaegarciaperedo · Answer 1 · 2020-09-08T03:46:57+02:00

Answer:

Glycogen is a polysaccharide and the enzyme, alpha-glucosidase, is not breaking it down into the monosaccharide glucose.

Explanation:

Pompe disease is an inheritable disorder that affects many parts of the body, especially the heart and other muscles.

People that are diagnosed with the disease present a defect in a gene called AAG. The enzyme alpha acid glucosidase is not present in the organism or it just does not work properly. These people have problems in processing the polysaccharide glycogen.

The AAG enzyme is located in the lysosomes, and its function is to decompose the polysaccharide glycogen (complex sugar) into the monosaccharide glucose (a simpler sugar). This last one is the source of energy of the organism.

The unproperly functioning of the enzyme causes the accumulation of glycogen in lysosomes of the macrophages.