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Answer:
Because replication only follows single strands, not double strands, of DNA.
Explanation:
As you can see in the figure below, the regions of the chromosome marked as I are on a double strand of DNA and replication proceeds only in regions of single strands of DNA.
Topoisomerase, is the enzyme responsible for binding the double strand of DNA and separating each strand, forming two single strands, before the replication bubble arrives, only then can replication continue.
For this reason, we can say that in the region of the chromosome marked as I, it will be necessary for the topoisomer to separate each strand of DNA for replication to proceed.
Replication best follows unmarried strands, now no longer double strands of DNA. Then, the topoisomerase binds in advance of every advancing replication fork in area II.
DNA Replication is the technique via way of means of which DNA makes a replica of itself at some point of molecular division. The separation of the 2 unmarried strands of DNA creates a ‘Y’ form known as a replication ‘fork’.
The separated strands will act as templates for making the brand-new strands of DNA. Therefore, The replication of DNA, best follows the unmarried strands, now no longer double strands of DNA.
Learn more about DNA replication here:
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