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A mutation that inserts or deletes one or two nucleotides is usually more harmful than a mutation that substitutes one base for another because -


A It changes one amino acid in the sequence of a protein

B it shifts the reading frame for the rest of the code causing many errors

C The codon consists of three nucleotides coding for an amino acid

D the chromosomes fail to separate resulting in trisomy 21

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The answer you're looking for is B.

If one or two nucleotides are added or deleted, they will cause a shift in the reading frame. This resulted in many errors.

Frame Shift Mutation:

  • There is code for every amino acid consecutively present in mRNA.
  • These codes are read by the ribosome to form proteins.
  • If one or two nucleotides are deleted or inserted, It completely changes the patern of codes.
  • Hence it will read differently and form a non-functioning protein.

Hence, we can conclude that If one or two nucleotides are added or deleted they will cause a shift in change the reading frame result in many errors.

For more about frame-shift mutation refer to the link:

https://brainly.com/question/15192321?referrer=searchResults

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