Answer:
Cells during division process cells reduce its size gradually and form an end association that leads to the Damage in DNA. Due to this disruption in DNA the cell signal to cause the cell to replicative senescence.
It is termed as the cell arrest, it this cell checkpoints are not present the telomeres keep on reducing its size that leads to M2 stage. It is shown by the researcghes the telomerase dysfunction is leads to cellular and organ cancer progression.
