Respuesta :
Answer: the LEAST effective replacement for the phrase "used great power": D) squandered great power
Explanation:
The phrase "used great power" means that the Sacramento region had great power/ great influence in the decade of the 1850s.
So "applied great power", "exerted great power" and "employed great power" could be considered synonyms of this phrase.
The phrase "squandered great power" would be wrong to use in this context, because "to squander" means to "waste" and Sacramento wasn't wasting its power - quite the contrary, as it's said in the text Sacramento had a powerful voice -> "Sacramento's influence was in large part due to its growth in commerce, particularly that portion related to transportation".