In humans, the correlation between recombination frequency and length of DNA sequence is, on average, 1 million bp per 1% RE During the process of mapping the Huntington disease gene (HD), it was found that HD was linked to a DNA marker called G8with an RF of 596. Surprisingly, when the HD gene was finally identified, its physical distance from G8was found to be about 500,000 bp, instead of the expected 5 million bp. How can this observation be explained?

As anticipated in the above inquiry, in view of 5% RF, the physical separation between HD quality and G8 DNA marker ought to be 5 million bp (50,00,000 bp), however genuine separation was seen as 5,00,000 bp. They have determined the separation between HD quality and G8 DNA marker by thinking about that the entire genome has a uniform recombination recurrence i.e 1% RF which gives 1 million bp.

In any case, here for this situation it is contrasting and here we are having multiple times increasingly cross overs [tex]\frac{5000000}{500000}=10[/tex] between HD quality and G8 DNA marker, that is the motivation behind why the separation was 5 lakh bp rather than 50 lakh base sets. Along these lines, the locale between HD quality and G8 DNA marker is having high recombination recurrence than anticipated and in view of the separation between HD quality and G8 DNA marker has diminished.