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If a segment of DNA were replicated without any errors, the replicated strand would have the following sequence of nucleotides:
5' - ACTACGTGA - 3'

Sort the following replicated DNA sequences by the type of point mutation each contains (frameshift, base substitution, or neither), as compared to the correct sequence shown above.
Sort the items into the appropriate name as frameshift mutation, base substitution mutation and or neither
5'-ACTCGTGA-3'
5'-ATTACGTGA-3'
5'-ACTACGTGT-3'
5'-ACTAAGTGA-3'

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BioWizard

5'-ACTCGTGA-3'-frameshift mutation (number of nucleotides in a DNA sequence is not divisible by three). deletion, one nucleotide in DNA is deleted, in this case A

5'-ATTACGTGA-3'- base substitution, C is substituted with T

5'-ACTACGTGT-3'- base substitution, A is substituted with T

5'-ACTAAGTGA-3'- base substitution, C is substituted with A

Substitution is a type of mutation in whichonly one base is changed. They can be:

• Nonsense mutations-when substitution leads to the formation of a stop codon instead of a codon

• Missense mutations-when one nucleotide is substituted and a different codon is formed

•       Silent mutations-when a nucleotide is substituted and the same amino acid is produced

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