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Familial hypercholesterolemia, an autosomal dominant disease, is five times more frequent in the afrikaner population of south africa than in the original population of europe from which the ancestors to the afrikaners immigrated. what does this demonstrate?

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This represents the example of founder effect.

The founder effect is a term in genetics that describes the loss of genetic variation as a result of new population formation by a very small number of individuals from a larger population. Small group of migrants (the afrikaner population of south Africa) that is not genetically representative of the larger population (Europe population) forms a new population with lower genetic variation.

Answer: Founder effect.

Explanation:

  • The founder effect is caused when a small group of individuals becomes separated from a larger population and move into a new area. This smaller population, moving to a new area forms the founder population.
  • Since a new population is established from a smaller population it leads to a loss of genetic variation and, this effect is known as founder effect and this is the reason why Familial hypercholesterolemia is more frequent in the afrikaner population

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