Answer;
-Lipid soluble molecules
Explanation;
The principal components of the plasma membrane are lipids (phospholipids and cholesterol), proteins, and carbohydrate groups that are attached to some of the lipids and proteins.
The arrangement of proteins in the plasma membrane involves the hydrophobic and hydrophilic regions found on the surfaces of the proteins.
-Hydrophobic regions associate with the hydrophobic interior of the plasma membrane and hydrophilic regions extend past the surface of the membrane into either the inside of the cell or the outer. Like the interior plasma membrane, lipid soluble molecules are also hydrophobic, they do not dissolve in water but in organic solvents.